Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge

• Main Authors: Cristan Herbert (Author), Jessica S. Siegle (Author), Alexander M. Shadie (Author), Stina Nikolaysen (Author), Linda Garthwaite (Author), Nicole G. Hansbro (Author), Paul S. Foster (Author), Rakesh K. Kumar (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Childhood exposure to environmental particulates increases the risk of development of asthma. The underlying mechanisms might include oxidant injury to airway epithelial cells (AEC). We investigated the ability of ambient environmental particulates to contribute to sensitization via the airw...