Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2

• Main Authors: Siru Wu (Author), Cong Lin (Author), Tianshu Zhang (Author), Bo Zhang (Author), Yushan Jin (Author), Hongshuang Wang (Author), Hongyuan Li (Author), Yibo Wang (Author), Xiaohui Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that can recognize lipopolysaccharides (LPS) and initiate the immune response, to protect the body from infection. However, excessive activation of TLR4 induced by LPS leads to substantial release of pro-inflammatory factors, which...