Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

• Main Authors: Bryan G. Harder (Author), Sen Peng (Author), Christopher P. Sereduk (Author), Andrej M. Sodoma (Author), Gaspar J. Kitange (Author), Joseph C. Loftus (Author), Jann N. Sarkaria (Author), Nhan L. Tran (Author)
• Format: Book
• Published: BMC, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulating evidence that TMZ induces stress-responsive cellular programs known...