The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications

• Main Authors: Shumin Ouyang (Author), Qiyi Zhang (Author), Linlin Lou (Author), Kai Zhu (Author), Zeyu Li (Author), Peiqing Liu (Author), Xiaolei Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reprogramming of cellular energy metabolism is considered an emerging feature of cancer. Mitochondrial metabolism plays a crucial role in cancer cell proliferation, survival, and metastasis. As a major mitochondrial NAD+-dependent deacetylase, sirtuin3 (SIRT3) deacetylates and regulates the enzymes...