Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease

• Main Authors: Věra Čertíková Chábová (Author), Petr Kujal (Author), Petra Škaroupková (Author), Zdeňka Varňourková (Author), Šárka Vacková (Author), Zuzana Husková (Author), Soňa Kikerlová (Author), Janusz Sadowski (Author), Elzbieta Kompanowska-Jezierska (Author), Iwona Baranowska (Author), Sung Hee Hwang (Author), Bruce D. Hammock (Author), John D. Imig (Author), Vladimír Tesař (Author), Ludek Červenka (Author)
• Format: Book
• Published: Karger Publishers, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: We found recently that increasing renal epoxyeicosatrienoic acids (EETs) levels by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, shows renoprotective actions and retards the progression of chronic kidney disease (CKD) in Ren-2 transgenic hyper...