Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA

• Main Authors: Vignesh N. Hariharan (Author), Takahiro Nakamura (Author), Minwook Shin (Author), Qi Tang (Author), Vyankat Sontakke (Author), Jillian Caiazzi (Author), Samuel Hildebrand (Author), Anastasia Khvorova (Author), Ken Yamada (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNAs (siRNAs) are revolutionizing the treatment of liver-associated indications. Yet, robust delivery to extrahepatic tissues remains a challenge. Conjugating lipids (e.g., docosanoic acid [DCA]) to siRNA supports extrahepatic delivery, but tissue accumulation remains lower than th...