Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans.

• Main Authors: Jean-Pierre Dangy (Author), Nicole Scherr (Author), Philipp Gersbach (Author), Melanie N Hug (Author), Raphael Bieri (Author), Claudio Bomio (Author), Jun Li (Author), Sylwia Huber (Author), Karl-Heinz Altmann (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of mycolactone.Using the B cell hybridoma technology...