Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans.

• Hauptverfasser: Jean-Pierre Dangy (Verfasst von), Nicole Scherr (Verfasst von), Philipp Gersbach (Verfasst von), Melanie N Hug (Verfasst von), Raphael Bieri (Verfasst von), Claudio Bomio (Verfasst von), Jun Li (Verfasst von), Sylwia Huber (Verfasst von), Karl-Heinz Altmann (Verfasst von), Gerd Pluschke (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of mycolactone.Using the B cell hybridoma technology...