Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport

• Main Authors: Sotiria Tavoulari (Author), Denis Lacabanne (Author), Gonçalo C. Pereira (Author), Chancievan Thangaratnarajah (Author), Martin S. King (Author), Jiuya He (Author), Suvagata R. Chowdhury (Author), Lisa Tilokani (Author), Shane M. Palmer (Author), Julien Prudent (Author), John E. Walker (Author), Edmund R.S. Kunji (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Citrin, the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, because it consists of three domains and forms a homo-dimer. Each protomer has an N-terminal calcium-binding domain with EF-hands, followed by...