Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system

• Main Authors: Yang Liu (Author), Juan Li (Author), Zhi Li (Author), Xing Tang (Author), Zhenzhong Zhang (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2017-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chromatography (UPLC-MS) method is developed to investigate its pharmacokinetics and b...