Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles

• Main Authors: Yanying Sun (Author), Zhenzhen Zhou (Author), Zhongling Shi (Author), Fabao Zhao (Author), Minghui Xie (Author), Zongji Zhuo (Author), Erik De Clercq (Author), Christophe Pannecouque (Author), Dongwei Kang (Author), Peng Zhan (Author), Xinyong Liu (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV-1 reverse transcriptase (RT) has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome (AIDS), but the inevitable drug resistance and side effects have always been major challenges faced by non-nucleoside reverse transcriptase inhibitors (NNRTIs). T...