Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia

• 主要な著者: Bella S. Guerrouahen (著者), Ibrahim Al-Hijji (著者), Arash Rafii Tabrizi (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2011-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called "niches." The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differentiation ability of HSC are regulated by two major el...