Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer

• Päätekijät: Qiong Shi (Tekijä), Xiaomei Ni (Tekijä), Ming Lei (Tekijä), Quansong Xia (Tekijä), Yan Dong (Tekijä), Qiao Zhang (Tekijä), Weiping Wang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: BMC, 2021-05-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Background Despite recent advances in diagnostic and therapeutic approaches for gastric cancer (GC), the survival of patients with advanced GC remains very low. Islet-1 (ISL1) is a LIM-homeodomain transcription factor, which is upregulated and promotes cell proliferation in GC. The exact me...