OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis

• Main Authors: Chunlei He (Author), Qiang Wu (Author), Zhaogan Zeng (Author), Yadong Yang (Author), Huabin He (Author), Meiyu Hu (Author), Sheng Liu (Author)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

AbstractBackgrounds The role of O-GlcNAc transferase (OGT)-induced O-linked N-acetylglucosaminylation (O-GlcNAcylation) has been reported in multiple human diseases. However, its specific functions in osteoarthritis (OA) progression remain undetermined.Objective This study focused on the target prot...