No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides

• Main Authors: David Aldo De Luca (Author), Paula Andrea Enz (Author), Ricardo Luis Galimberti (Author), Adriana Raquel Rinflerch (Author)
• Format: Book
• Published: Sociedade Brasileira de Dermatologia, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract: The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation. We aimed to detect by PCR the most frequent exon mutations in seventeen plaque-stage MF patients,...