Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol

• Autors principals: Anne Schlegel (Autor), Cyril Buhler (Autor), Flavien Devun (Autor), Céline Agrario (Autor), Saïk Urien (Autor), François Lokiec (Autor), Jian-Sheng Sun (Autor), Marie Dutreix (Autor)
• Format: Llibre
• Publicat: Elsevier, 2012-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Increased DNA repair activity in cancer cells is one of their primary mechanisms of resistance to current radio- and chemotherapies. The molecule coDbait is the first candidate in a new class of drugs that target the double-strand DNA break repair pathways with the aim of overcoming these resistance...