Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol

• Main Authors: Anne Schlegel (Author), Cyril Buhler (Author), Flavien Devun (Author), Céline Agrario (Author), Saïk Urien (Author), François Lokiec (Author), Jian-Sheng Sun (Author), Marie Dutreix (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increased DNA repair activity in cancer cells is one of their primary mechanisms of resistance to current radio- and chemotherapies. The molecule coDbait is the first candidate in a new class of drugs that target the double-strand DNA break repair pathways with the aim of overcoming these resistance...