Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1-4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon<sup>®</sup> VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ's poor solubil...

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Main Authors: Hetvi Triboandas (Author), Kendal Pitt (Author), Mariana Bezerra (Author), Delphine Ach-Hubert (Author), Walkiria Schlindwein (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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