Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

• Main Authors: Hetvi Triboandas (Author), Kendal Pitt (Author), Mariana Bezerra (Author), Delphine Ach-Hubert (Author), Walkiria Schlindwein (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1-4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon^® VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ's poor solubil...