Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

• Main Authors: Zhilei Hu (Author), Yu Wang (Author), Xiaoxin Gao (Author), Yuyao Zhang (Author), Chenhao Liu (Author), Yu Zhai (Author), Xian Chang (Author), Haiyin Li (Author), Yueyang Li (Author), Jinhui Lou (Author), Changqing Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low back pain is thought to be mainly caused by intervertebral disc degeneration (IVDD), and there is a lack of effective treatments. Cellular senescence and matrix degradation are important factors that cause disc degeneration. Mitochondrial dysfunction induced by oxidative stress is an important m...