Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

• Main Authors: Alena Akhmetshina (Author), Valentina Bianco (Author), Ivan Bradić (Author), Melanie Korbelius (Author), Anita Pirchheim (Author), Katharina B. Kuentzel (Author), Thomas O. Eichmann (Author), Helga Hinteregger (Author), Dagmar Kolb (Author), Hansjoerg Habisch (Author), Laura Liesinger (Author), Tobias Madl (Author), Wolfgang Sattler (Author), Branislav Radović (Author), Simon Sedej (Author), Ruth Birner-Gruenberger (Author), Nemanja Vujić (Author), Dagmar Kratky (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...