FUNCTIONAL GENOMICS IDENTIFIES TIS21-DEPENDENT MECHANISMS AND PUTATIVE CANCER DRUG TARGETS UNDERLYING MEDULLOBLASTOMA SHH-TYPE DEVELOPMENT

• मुख्य लेखकों: Giulia Gentile (लेखक), Manuela Ceccarelli (लेखक), Laura Micheli (लेखक), Felice Tirone (लेखक), Sebastiano Cavallaro (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We have recently generated a novel medulloblastoma (MB) mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1+-Tis21KO).ts main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs). By genomic analysis of GCPs in vivo, we identifi...