Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase

• Asıl Yazarlar: Mikhail Krasavin (Yazar), Raivis Žalubovskis (Yazar), Aiga Grandāne (Yazar), Ilona Domračeva (Yazar), Petr Zhmurov (Yazar), Claudiu T. Supuran (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and - hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia a...