Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase

The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and - hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia a...

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Main Authors: Mikhail Krasavin (Author), Raivis Žalubovskis (Author), Aiga Grandāne (Author), Ilona Domračeva (Author), Petr Zhmurov (Author), Claudiu T. Supuran (Author)
Formato: Livro
Publicado em: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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