The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer

• Main Authors: Maha-Hamadien Abdulla (Author), Aminah Ahmad Alzailai (Author), Mansoor-Ali (Author), Rehan Ahmad (Author), Sabiha Fatima (Author), Ahmed Zubaidi (Author), Thamer bin Traiki (Author), Amer Mahmood (Author), Reem Hamoud Alrashoudi (Author), Zahid Khan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: There is a steady increase in colorectal cancer (CRC) incidences worldwide; at diagnosis, about 20 percent of cases show metastases. The transforming growth factor-beta (TGF-β) signaling pathway is one of the critical pathways that influence the expression of cadherins allowing the epi...