Bone marrow mesenchymal stem cells expressing Neat-1, Hotair-1, miR-21, miR-644, and miR-144 subsided cyclophosphamide-induced ovarian insufficiency by remodeling the IGF-1-kisspeptin system, ovarian apoptosis, and angiogenesis

• Main Authors: Amany I. Ahmed (Author), Mohamed F. Dowidar (Author), Asmaa F. Negm (Author), Hussein Abdellatif (Author), Asma Alanazi (Author), Mohammed Alassiri (Author), Walaa Samy (Author), Dina Mohamed Mekawy (Author), Eman M. A. Abdelghany (Author), Nesma I. El-Naseery (Author), Mohamed A. Ibrahem (Author), Emad Ali Albadawi (Author), Wed Salah (Author), Mamdouh Eldesoqui (Author), Emil Tîrziu (Author), Iulia Maria Bucur (Author), Ahmed Hamed Arisha (Author), Tarek Khamis (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ovarian insufficiency is one of the common reproductive disorders affecting women with limited therapeutic aids. Mesenchymal stem cells have been investigated in such disorders before yet, the exact mechanism of MSCs in ovarian regeneration regarding their epigenetic regulation remains elus...