Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.

• Main Authors: Andrea Trochine (Author), Darren J Creek (Author), Paula Faral-Tello (Author), Michael P Barrett (Author), Carlos Robello (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is not fully und...