Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

• Asıl Yazarlar: Wai-Lok Yau (Yazar), Thierry Blisnick (Yazar), Jean-François Taly (Yazar), Manuela Helmer-Citterich (Yazar), Cordelia Schiene-Fischer (Yazar), Olivier Leclercq (Yazar), Jing Li (Yazar), Dirk Schmidt-Arras (Yazar), Miguel A Morales (Yazar), Cedric Notredame (Yazar), Daniel Romo (Yazar), Philippe Bastin (Yazar), Gerald F Späth (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

BACKGROUND: Cyclosporin A (CsA) has important anti-microbial activity against parasites of the genus Leishmania, suggesting CsA-binding cyclophilins (CyPs) as potential drug targets. However, no information is available on the genetic diversity of this important protein family, and the mechanisms un...