Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

• Main Authors: Wai-Lok Yau (Author), Thierry Blisnick (Author), Jean-François Taly (Author), Manuela Helmer-Citterich (Author), Cordelia Schiene-Fischer (Author), Olivier Leclercq (Author), Jing Li (Author), Dirk Schmidt-Arras (Author), Miguel A Morales (Author), Cedric Notredame (Author), Daniel Romo (Author), Philippe Bastin (Author), Gerald F Späth (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Cyclosporin A (CsA) has important anti-microbial activity against parasites of the genus Leishmania, suggesting CsA-binding cyclophilins (CyPs) as potential drug targets. However, no information is available on the genetic diversity of this important protein family, and the mechanisms un...