Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression

• Main Authors: Andrey A. Rosenkranz (Author), Tatiana A. Slastnikova (Author), Tatiana A. Karmakova (Author), Maria S. Vorontsova (Author), Natalia B. Morozova (Author), Vasiliy M. Petriev (Author), Alexey S. Abrosimov (Author), Yuri V. Khramtsov (Author), Tatiana N. Lupanova (Author), Alexey V. Ulasov (Author), Raisa I. Yakubovskaya (Author), Georgii P. Georgiev (Author), Alexander S. Sobolev (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gamma-ray emitting 111In, which is extensively used for imaging, is also a source of short-range Auger electrons (AE). While exhibiting negligible effect outside cells, these AE become highly toxic near DNA within the cell nucleus. Therefore, these radionuclides can be used as a therapeutic anticanc...