Ascorbic acid 6-palmitate modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated BV-2 cells via PERK/elF2α mediated endoplasmic reticulum stress

• Main Authors: Qian Li (Author), Yao Wu (Author), Xue-shen Chen (Author), Tao Zeng (Author), Lin-ling Liu (Author), Zi-qi Feng (Author), Dan-yang Liu (Author), Ling Zhu (Author), Li-hong Wan (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Neuroinflammation-mediated microglia polarization is a major process in various central nervous system (CNS) diseases. Endoplasmic reticulum (ER) stress contributes to the inflammatory signals as well as to microglia polarization in lipopolysaccharide (LPS) induced neuroinflammat...