In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology.

• Главные авторы: Tânia A Costa (Автор), Silvia B Bazan (Автор), Claudia Feriotti (Автор), Eliseu F Araújo (Автор), Ênio J Bassi (Автор), Flávio V Loures (Автор), Vera L G Calich (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предметы: article
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BACKGROUND: Cellular immunity is the main defense mechanism in paracoccidioidomycosis (PCM), the most important systemic mycosis in Latin America. Th1 immunity and IFN-γ activated macrophages are fundamental to immunoprotection that is antagonized by IL-10, an anti-inflammatory cytokine. Both in hum...