A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression

• Main Authors: Daniel Meraviglia-Crivelli (Author), Helena Villanueva (Author), Ashwathi Puravankara Menon (Author), Angelina Zheleva (Author), Beatriz Moreno (Author), María Villalba-Esparza (Author), Fernando Pastor (Author)
• 格式: 圖書
• 出版: Elsevier, 2022-09-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments. There is an unmet need to develop a feasible clinical therapeutic platform to increase the rate of respon...