Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3β Signaling Cascades and Afferent Arteriolar Activity

• Main Authors: Gensheng Zhang (Author), Qin Wang (Author), Wenwen Wang (Author), Minghua Yu (Author), Suping Zhang (Author), Nan Xu (Author), Suhan Zhou (Author), Xiaoyun Cao (Author), Xiaodong Fu (Author), Zufu Ma (Author), Ruisheng Liu (Author), Jianhua Mao (Author), En Yin Lai (Author)
• Format: Book
• Published: Karger Publishers, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Free radical scavenger tempol is a protective antioxidant against ischemic injury. Tubular epithelial apoptosis is one of the main changes in the renal ischemia/reperfusion (I/R) injury. Meanwhile some proteins related with apoptosis and inflammation are also involved in renal I/R i...