Downregulation of the <i>Glo1</i> Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

• 主要な著者: Jan Šilhavý (著者), Hana Malínská (著者), Martina Hüttl (著者), Irena Marková (著者), Olena Oliyarnyk (著者), Petr Mlejnek (著者), Miroslava Šimáková (著者), František Liška (著者), Ludmila Kazdová (著者), Radka Moravcová (著者), Jiří Novotný (著者), Michal Pravenec (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, coded by the <i>Glo1</i> gene, serves as t...