Downregulation of the <i>Glo1</i> Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

• Main Authors: Jan Šilhavý (Author), Hana Malínská (Author), Martina Hüttl (Author), Irena Marková (Author), Olena Oliyarnyk (Author), Petr Mlejnek (Author), Miroslava Šimáková (Author), František Liška (Author), Ludmila Kazdová (Author), Radka Moravcová (Author), Jiří Novotný (Author), Michal Pravenec (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, coded by the <i>Glo1</i> gene, serves as t...