Radiotherapy-Induced Skin Reactions Induce Fibrosis Mediated by TGF-β1 Cytokine

• Main Authors: Cherley Borba Vieira de Andrade (Author), Isalira Peroba Rezende Ramos (Author), Alan César Nunes de Moraes (Author), Ana Lúcia Rosa do Nascimento (Author), Camila Salata (Author), Regina Coeli dos Santos Goldenberg (Author), Jorge José de Carvalho (Author), Carlos Eduardo Veloso de Almeida (Author)
• Format: Book
• Published: SAGE Publishing, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: This study aimed to investigate radiation-induced lesions on the skin in an experimental animal model. Methods and Materials: Cutaneous wounds were induced in Wistar rats by 4 MeV energy electron beam irradiation, using a dose rate of 240 cGy/min, for 3 different doses (10 Gy, 40 Gy, and 60...