CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation

CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation

CD38, a surface receptor that controls signals in immunocompetent cells, is densely expressed by cells of multiple myeloma (MM). The immune system of MM patients appears as functionally impaired, with qualitative and quantitative defects in T cell immune responses. This work answers the issue whethe...

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Main Authors: Giorgio Fedele (Author), Marco Di Girolamo (Author), Umberto Recine (Author), Raffaella Palazzo (Author), Francesca Urbani (Author), Alberto L. Horenstein (Author), Fabio Malavasi (Author), Clara Maria Ausiello (Author)
Format: Book
Published: Hindawi Limited, 2013-01-01T00:00:00Z.
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