Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

• मुख्य लेखकों: Shurong Hou (लेखक), Juan Diez (लेखक), Chao Wang (लेखक), Christoph Becker-Pauly (लेखक), Gregg B. Fields (लेखक), Thomas Bannister (लेखक), Timothy P. Spicer (लेखक), Louis D. Scampavia (लेखक), Dmitriy Minond (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer's. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical development. Moreover, inhibitors of other metzincins de...