Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

• 主要な著者: Shurong Hou (著者), Juan Diez (著者), Chao Wang (著者), Christoph Becker-Pauly (著者), Gregg B. Fields (著者), Thomas Bannister (著者), Timothy P. Spicer (著者), Louis D. Scampavia (著者), Dmitriy Minond (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer's. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical development. Moreover, inhibitors of other metzincins de...