Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

• Main Authors: Shurong Hou (Author), Juan Diez (Author), Chao Wang (Author), Christoph Becker-Pauly (Author), Gregg B. Fields (Author), Thomas Bannister (Author), Timothy P. Spicer (Author), Louis D. Scampavia (Author), Dmitriy Minond (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer's. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical development. Moreover, inhibitors of other metzincins de...