Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies

• Main Authors: Stefania Pizzimenti (Author), Simone Ribero (Author), Marie Angele Cucci (Author), Margherita Grattarola (Author), Chiara Monge (Author), Chiara Dianzani (Author), Giuseppina Barrera (Author), Giuliana Muzio (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic alterations, present in approximately 50% of all melanoma cases. The use of specific inhibitors towards mutant BRAF variants a...