CX08005, a Protein Tyrosine Phosphatase 1B Inhibitor, Attenuated Hepatic Lipid Accumulation and Microcirculation Dysfunction Associated with Nonalcoholic Fatty Liver Disease

• Main Authors: Jiang Li (Author), Xiaolin Zhang (Author), Jinying Tian (Author), Juan Li (Author), Xuechen Li (Author), Song Wu (Author), Yuying Liu (Author), Jingyan Han (Author), Fei Ye (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonalcoholic fatty liver disease (NAFLD) is one of the common metabolic diseases characterized by hepatic lipid accumulation. Insulin resistance and microcirculation dysfunction are strongly associated with NAFLD. CX08005, an inhibitor of PTP1B with the IC₅₀ of 0.75 ± 0.07 μM,...