Vascular Endothelial Growth Factor Augments Arginine Transport and Nitric Oxide Generation via a KDR Receptor Signaling Pathway

• Main Authors: Moshe Shashar (Author), Tamara Chernichovski (Author), Oren Pasvolsky (Author), Sharon Levi (Author), Ayelet Grupper (Author), Rami Hershkovitz (Author), Talia Weinstein (Author), Idit F. Schwartz (Author)
• Format: Book
• Published: Karger Publishers, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Vascular endothelial growth factor (VEGF) is an endothelium-specific peptide that stimulates angiogenesis via two receptor tyrosine kinases, Flt-1 and KDR. Endothelial nitric oxide synthase (eNOS) plays a major role in VEGF signaling. Delivery of arginine to membrane bound eNOS by t...