Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

• Main Authors: Johanna Ebmeyer (Author), Abdulkarim Najjar (Author), Daniela Lange (Author), Mareike Boettcher (Author), Silja Voß (Author), Katrin Brandmair (Author), Jaqueline Meinhardt (Author), Jochen Kuehnl (Author), Nicola J. Hewitt (Author), Christopher-Tilman Krueger (Author), Andreas Schepky (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We performed an ab initio next-generation risk assessment (NGRA) for a fragrance ingredient, benzyl salicylate (BSal), to demonstrate how cosmetic ingredients can be evaluated for systemic toxicity endpoints based on non-animal approaches. New approach methodologies (NAMs) used to predict the intern...