Combined Immunodeficiency With Late-Onset Progressive Hypogammaglobulinemia and Normal B Cell Count in a Patient With RAG2 Deficiency

• Asıl Yazarlar: Mayra B. Dorna (Yazar), Pamela F. A. Barbosa (Yazar), Andréia Rangel-Santos (Yazar), Krisztian Csomos (Yazar), Boglarka Ujhazi (Yazar), Joseph F. Dasso (Yazar), Daniel Thwaites (Yazar), Joan Boyes (Yazar), Sinisa Savic (Yazar), Jolan E. Walter (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Proteins expressed by recombination activating genes 1 and 2 (RAG1/2) are essential in the process of V(D)J recombination that leads to generation of the T and B cell repertoires. Clinical and immunological phenotypes of patients with RAG deficiencies correlate well to the degree of impaired RAG act...