A Small Molecule Targeting the Intracellular Tyrosine Kinase Domain of ROR1 (KAN0441571C) Induced Significant Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells

A Small Molecule Targeting the Intracellular Tyrosine Kinase Domain of ROR1 (KAN0441571C) Induced Significant Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells

The ROR1 receptor tyrosine kinase is expressed in embryonic tissues but is absent in normal adult tissues. ROR1 is of importance in oncogenesis and is overexpressed in several cancers, such as NSCLC. In this study, we evaluated ROR1 expression in NSCLC patients (N = 287) and the cytotoxic effects of...

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Main Authors: Amineh Ghaderi (Author), Mohammad-Ali Okhovat (Author), Jemina Lehto (Author), Luigi De Petris (Author), Ehsan Manouchehri Doulabi (Author), Parviz Kokhaei (Author), Wen Zhong (Author), Georgios Z. Rassidakis (Author), Elias Drakos (Author), Ali Moshfegh (Author), Johan Schultz (Author), Thomas Olin (Author), Anders Österborg (Author), Håkan Mellstedt (Author), Mohammad Hojjat-Farsangi (Author)
Format: Book
Published: MDPI AG, 2023-04-01T00:00:00Z.
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