In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay

• Main Authors: Abdullah Khalil Rabba (Author), Luqin Si (Author), Kewen Xue (Author), Ming Li (Author), Gao Li (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2011-04-01T00:00:00Z.
• Fag: article
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PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotecan, and to quantify the amount of its cytotoxic metabolite SN-38 that is intestinally excreted (exsorped) as a predictor of intestinal toxicity, and to assess the effect of p-glycoprotein (p-gp) inhibi...