A potent antiarrhythmic drug N-methyl berbamine extends the action potential through inhibiting both calcium and potassium currents

• Main Authors: Huiyuan Hu (Author), Shi Zhou (Author), Xiaodong Sun (Author), Yingchun Xue (Author), Ling Yan (Author), Xuanxuan Sun (Author), Ming Lei (Author), Jinming Li (Author), Xiaorong Zeng (Author), Liying Hao (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N-methyl berbamine (N-MB) is a berberine derivative. Its analogue berbamine has been reported to have remarkable antiarrhythmic and ischemic protective effects. However, the pharmacological effects of N-MB are ill-defined. In this study, molecular docking was used to evaluate the binding of N-MB to...