Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers

• Main Authors: Jörg Duschmalé (Author), Adrian Schäublin (Author), Erik Funder (Author), Steffen Schmidt (Author), Łukasz J. Kiełpiński (Author), Helle Nymark (Author), Klaus Jensen (Author), Troels Koch (Author), Martina Duschmalé (Author), Erich Koller (Author), Marianne Ravn Møller (Author), Simone Schadt (Author), Christophe Husser (Author), Andreas Brink (Author), Sabine Sewing (Author), Tanja Minz (Author), Jesper Wengel (Author), Konrad Bleicher (Author), Meiling Li (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The introduction of sulfur into the phosphate linkage of chemically synthesized oligonucleotides creates the stereocenters on phosphorus atoms. Researchers have valued the nature of backbone stereochemistry and early on investigated drug properties for the individual stereocenters in dimers or short...