Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

• Hlavní autoři: Karolina Cierluk (Autor), Wojciech Szlasa (Autor), Joanna Rossowska (Autor), Mounir Tarek (Autor), Anna Szewczyk (Autor), Jolanta Saczko (Autor), Julita Kulbacka (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2020-11-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing. In the new conformation, transport between mitochondria and cytoplasm is altered, which leads t...