Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing. In the new conformation, transport between mitochondria and cytoplasm is altered, which leads t...

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Main Authors: Karolina Cierluk (Author), Wojciech Szlasa (Author), Joanna Rossowska (Author), Mounir Tarek (Author), Anna Szewczyk (Author), Jolanta Saczko (Author), Julita Kulbacka (Author)
Format: Book
Published: Elsevier, 2020-11-01T00:00:00Z.
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3rd Floor Main Library

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