Palmitic Acid Methyl Ester Induces G2/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway

• Main Authors: Jian-Hong Lin (Author), Pei-Ching Ting (Author), Wen-Sen Lee (Author), Hung-Wen Chiu (Author), Chun-An Chien (Author), Chin-Hung Liu (Author), Li-Yi Sun (Author), Kun-Ta Yang (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow-derived mesenchymal cells (BM-MSCs) are able to differentiate into adipocytes, which can secrete adipokines to affect BM-MSC proliferation and differentiation. Recent evidences indicated that adipocytes can secrete fatty acid metabolites, such as palmitic acid methyl ester (PAME), which...