The Covert Surge: Murine Bile Acid Levels Are Associated With Pruritus in Pediatric Autoimmune Sclerosing Cholangitis

• Main Authors: Katharina Meinel (Author), Doloresz Szabo (Author), Antal Dezsofi (Author), Sina Pohl (Author), Tanja Strini (Author), Theresa Greimel (Author), Victor Aguiriano-Moser (Author), Harald Haidl (Author), Martin Wagner (Author), Axel Schlagenhauf (Author), Jörg Jahnel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectivesThe exact etiology of pruritus in chronic cholestasis is unknown. Pruritus intensity does not correlate with common biochemical indices and there is a lack of biomarkers guiding diagnosis and treatment. We explored profiles of bile acids (BA) and muricholic acids (MCA) as well as autotaxin...