A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.

• Главные авторы: Stephen Muhi (Автор), Joshua Osowicki (Автор), Daniel O'Brien (Автор), Paul D R Johnson (Автор), Sacha Pidot (Автор), Marcel Doerflinger (Автор), Julia L Marshall (Автор), Marc Pellegrini (Автор), James McCarthy (Автор), Timothy P Stinear (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2023-06-01T00:00:00Z.
• Предметы: article
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Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and...