A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.

• Main Authors: Stephen Muhi (Author), Joshua Osowicki (Author), Daniel O'Brien (Author), Paul D R Johnson (Author), Sacha Pidot (Author), Marcel Doerflinger (Author), Julia L Marshall (Author), Marc Pellegrini (Author), James McCarthy (Author), Timothy P Stinear (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and...