ROS-Responsive and pH-Sensitive Aminothiols Dual-Prodrug for Radiation Enteritis

• Main Authors: Yuanfang Chen (Author), Yuwei Yang (Author), Haikang Tang (Author), Ziqi Zhang (Author), Xiaoliang Zhou (Author), Wenqing Xu (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiation exposure can immediately trigger a burst of reactive oxygen species (ROS), which can induce severe cell death and long-term tissue damage. Therefore, instantaneous release of sufficient radioprotective drugs is vital to neutralize those accumulated ROS in IR-exposed areas. To achieve this...