The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant <it>FMR1 </it>gene <it>in vitro</it>

• Egile Nagusiak: Tabolacci Elisabetta (Egilea), Pirozzi Filomena (Egilea), Gomez-Mancilla Baltazar (Egilea), Gasparini Fabrizio (Egilea), Neri Giovanni (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2012-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Fragile X syndrome (FXS), the leading cause of inherited mental retardation, is due to expansion and methylation of a CGG sequence in the <it>FMR1 </it>gene, which result in its silencing and consequent absence of FMRP pr...