The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant <it>FMR1 </it>gene <it>in vitro</it>

• Main Authors: Tabolacci Elisabetta (Author), Pirozzi Filomena (Author), Gomez-Mancilla Baltazar (Author), Gasparini Fabrizio (Author), Neri Giovanni (Author)
• Format: Book
• Published: BMC, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Fragile X syndrome (FXS), the leading cause of inherited mental retardation, is due to expansion and methylation of a CGG sequence in the <it>FMR1 </it>gene, which result in its silencing and consequent absence of FMRP pr...