Enzymatic approaches for profiling cytosine methylation and hydroxymethylation

• मुख्य लेखकों: Tong Wang (लेखक), Christian E. Loo (लेखक), Rahul M. Kohli (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: In mammals, modifications to cytosine bases, particularly in cytosine-guanine (CpG) dinucleotide contexts, play a major role in shaping the epigenome. The canonical epigenetic mark is 5-methylcytosine (5mC), but oxidized versions of 5mC, including 5-hydroxymethylcytosine (5hmC), are now...